Beyond Binding: The Outcomes of Antibody-Dependent Complement Activation in Human Malaria

D Rathnayake; EH Aitken; SJ Rogerson

Journal article

Beyond Binding: The Outcomes of Antibody-Dependent Complement Activation in Human Malaria

D Rathnayake, EH Aitken, SJ Rogerson

Frontiers in Immunology | Published : 2021

DOI: 10.3389/fimmu.2021.683404

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Abstract

Antibody immunity against malaria is effective but non-sterile. In addition to antibody-mediated inhibition, neutralisation or opsonisation of malaria parasites, antibody-mediated complement activation is also important in defense against infection. Antibodies form immune complexes with parasite-derived antigens that can activate the classical complement pathway. The complement system provides efficient surveillance for infection, and its activation leads to parasite lysis or parasite opsonisation for phagocytosis. The induction of complement-fixing antibodies contributes significantly to the development of protective immunity against clinical malaria. These complement-fixing antibodies can ..

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University of Melbourne Researchers

Elizabeth Aitken Author

Stephen Rogerson Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

DR is supported by the Melbourne Research Scholarship from the University of Melbourne and Miller Foundation Top-up Scholarship. The work of EA and SR is supported by grants from the National Health and Medical Research Council of Australia (GNT1092789 and GNT1143946), and by the Centre for Research Excellence in Malaria Elimination (GNT1134989).